Seminars in Colon & Rectal Surgery
Volume 17, Issue 4 , Pages 199-205 , December 2006

Alteration of the Tight Junction Complex in Intestinal Inflammation Career Development Award #001

  • Lisa S. Poritz, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: Lisa S. Poritz, MD, Associate Professor of Surgery, Section of Colon and Rectal Surgery, H137, The Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033.

References 

  1. Hollander D, Vadheim CM, Brettholz E, et al. Increased intestinal permeability in patients with Crohn’s disease and their relatives a possible etiologic factor. Ann Intern Med. 1986;105:883–885
  2. Wyatt J, Vogelsang H, Hubl W, et al. Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet. 1993;341:1437–1439
  3. Pironi L, Miglioli M, Ruggeri E, et al. Relationship between intestinal permeability to [51Cr]EDTA and inflammatory activity in asymptomatic patients with Crohn’s disease. Dig Dis Sci. 1990;35:582–588
  4. Hilsden RJ, Meddings JB, Hardin J, et al. Intestinal permeability and postheparin plasma diamine oxidase activity in the prediction of Crohn’s disease relapse. Inflamm Bowel Dis. 1999;5:85–91
  5. D’Inca R, Di Leo V, Corrao G, et al. Intestinal permeability test as a predictor of clinical course in Crohn’s disease. Am J Gastoenterol. 1990;94:2956–2960
  6. Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions (IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokine, and immune cells). Am J Physiol Gastrointest Liver Physiol. 2000;279:G851–G857
  7. Itoh M, Furuse M, Morita K, et al. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999;147:1351–1363
  8. Fanning AS, Jameson BJ, Jesaitis LA, et al. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem. 1998;273:29745–29753
  9. Niesser M, Vol BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol. 1995;101:428
  10. Poritz LS, Garver K, Tilberg AF, et al. Tumor necrosis factor alpha disrupts tight junction assembly. J Surg Res. 2004;116:14–18
  11. Okayasu I, Hatakeyama S, Yamada M, et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990;98:694–702
  12. Cooper HS, Murthy SNS, Shah RS, et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69:238–249
  13. Poritz LS, Garver KI, Green C, et al: Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis. J Surg Res (in press).

PII: S1043-1489(06)00091-1

doi: 10.1053/j.scrs.2006.10.007

Seminars in Colon & Rectal Surgery
Volume 17, Issue 4 , Pages 199-205 , December 2006

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