Seminars in Colon & Rectal Surgery
Volume 19, Issue 1 , Pages 26-29 , March 2008

Lymph Node Evaluation and Survival in Stage II and III Colon Cancer

  • Brian Badgwell, MD
  • ,
  • George J. Chang, MD, MS

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: George J. Chang, MD, MS, Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Blvd., Unit 444, Houston, TX 77030.

References 

  1. Cohen AM, Tremiterra S, Candela F, et al. Prognosis of node-positive colon cancer. Cancer. 1991;67(7):1859–1861
  2. Iversen LH, Harling H, Laurberg S, et al. Influence of caseload and surgical specialty on outcome following surgery for colorectal cancer: a review of evidence Part 2: long-term outcome. Colorectal Dis. 2007;9(1):38–46
  3. Nelson H, Petrelli N, Carlin A, et al. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst. 2001;93(8):583–596
  4. Otchy D, Hyman NH, Simmang C, et al. Practice parameters for colon cancer. Dis Colon Rectum. 2004;47(8):1269–1284
  5. Hermanek P. [Oncologic surgery/pathologic-anatomic viewpoint]. Langenbecks Arch Chir Suppl Kongressbd. 1991;277–281
  6. Compton CC. Updated protocol for the examination of specimens from patients with carcinomas of the colon and rectum, excluding carcinoid tumors, lymphomas, sarcomas, and tumors of the vermiform appendix: a basis for checklists (Cancer Committee). Arch Pathol Lab Med. 2000;124(7):1016–1025
  7. Compton CC. Key issues in reporting common cancer specimens: problems in pathologic staging of colon cancer. Arch Pathol Lab Med. 2006;130(3):318–324
  8. Goldstein NS. Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities. Am J Surg Pathol. 2002;26(2):179–189
  9. Swanson RS, Compton CC, Stewart AK, et al. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol. 2003;10(1):65–71
  10. Sarli L, Bader G, Iusco D, et al. Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer. 2005;41(2):272–279
  11. Le Voyer TE, Sigurdson ER, Hanlon AL, et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol. 2003;21(15):2912–2919
  12. Baxter NN, Virnig DJ, Rothenberger DA, et al. Lymph node evaluation in colorectal cancer patients: a population-based study. J Natl Cancer Inst. 2005;97(3):219–225
  13. Chang GJ, Rodriguez-Bigas MA, Skibber JM, et al. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst. 2007;99(6):433–441
  14. Prandi M, Lionetto R, Bini A, et al. Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large scale adjuvant trial. Ann Surg. 2002;235(4):458–463
  15. Bui L, Rempel E, Reeson D, et al. Lymph node counts, rates of positive lymph nodes, and patient survival for colon cancer surgery in Ontario, Canada: a population-based study. J Surg Oncol. 2006;93(6):439–445
  16. Carloss H, Huang B, Cohen A, et al. The impact of number of lymph nodes removed on five-year survival in stage II colon and rectal cancer. J Ky Med Assoc. 2004;102(8):345–347
  17. Cserni G, Vinh-Hung V, Burzykowski T. Is there a minimum number of lymph nodes that should be histologically assessed for a reliable nodal staging of T3N0M0 colorectal carcinomas?. J Surg Oncol. 2002;81(2):63–69
  18. Jestin P, Pahlman L, Glimelius B, et al. Cancer staging and survival in colon cancer is dependent on the quality of the pathologists’ specimen examination. Eur J Cancer. 2005;41(14):2071–2078
  19. Caplin S, Cerottini JP, Bosman FT, et al. For patients with Dukes’ B (TNM Stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis. Cancer. 1998;83(4):666–672
  20. Law CH, Wright FC, Rapanos T, et al. Impact of lymph node retrieval and pathological ultra-staging on the prognosis of stage II colon cancer. J Surg Oncol. 2003;84(3):120–126
  21. Cianchi F, Palomba A, Boddi V, et al. Lymph node recovery from colorectal tumor specimens: recommendation for a minimum number of lymph nodes to be examined. World J Surg. 2002;26(3):384–389
  22. Yoshimatsu K, Ishibashi K, Umehara A, et al. How many lymph nodes should be examined in Dukes’ B colorectal cancer? (Determination on the basis of cumulative survival rate). Hepatogastroenterology. 2005;52(66):1703–1706
  23. Gumus M, Yumuk PF, Atalay G, et al. What is the optimal number of lymph nodes to be dissected in colorectal cancer surgery?. Tumori. 2005;91(2):168–172
  24. Berberoglu U. Prognostic significance of total lymph node number in patients with T1-4N0M0 colorectal cancer. Hepatogastroenterology. 2004;51(60):1689–1693
  25. Wong JH, Bowles BJ, Bueno R, et al. Impact of the number of negative nodes on disease-free survival in colorectal cancer patients. Dis Colon Rectum. 2002;45(10):1341–1348
  26. Ratto C, Sofo L, Ippoliti M, et al. Accurate lymph-node detection in colorectal specimens resected for cancer is of prognostic significance. Dis Colon Rectum. 1999;42(2):143–154discussion 154-158
  27. Chen SL, Bilchik AJ. More extensive nodal dissection improves survival for stages I to III of colon cancer: a population-based study. Ann Surg. 2006;244(4):602–610
  28. Johnson PM, Porter GA, Ricciardi R, et al. Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. J Clin Oncol. 2006;24(22):3570–3575
  29. Lemmens VE, Verheij CD, Janssen-Heijnen ML, et al. Mixed adherence to clinical practice guidelines for colorectal cancer in the Southern Netherlands in 2002. Eur J Surg Oncol. 2006;32(2):168–173
  30. Wright FC, Law CH, Last L, et al. Lymph node retrieval and assessment in stage II colorectal cancer: a population-based study. Ann Surg Oncol. 2003;10(8):903–909
  31. Smith AJ, Law CH, Khalifa MA, et al. Multimodal CME for surgeons and pathologists improves colon cancer staging. J Cancer Educ. 2003;18(2):81–86
  32. Rajput A, Skibber J, Engstrom P, et al. Meeting the 12 lymph nodes (LN) benchmark in colorectal cancer surgery: a comparison of NCCN and SEER data. J Clin Oncol. 2007;25(suppl 18):4015;(Meeting Abstracts)
  33. Wong SL, Ji H, Hollenbeck BK, et al. Hospital lymph node examination rates and survival after resection for colon cancer. JAMA. 2007;298(18):2149–2154
  34. Eloubeidi MA, Desmond R, Arguedas MR, et al. Prognostic factors for the survival of patients with esophageal carcinoma in the U.S.: the importance of tumor length and lymph node status. Cancer. 2002;95(7):1434–1443
  35. Woodward WA, Vinh-Hung V, Ueno NT, et al. Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol. 2006;24(18):2910–2916
  36. Meyers MO, Hollis DR, Mayer RJ, et al. Ratio of metastatic to examined lymph nodes is a powerful predictor of overall survival in rectal cancer: an analysis of Intergroup 0114. J Clin Oncol. 2007;25(suppl 18):4006;(Meeting Abstracts)
  37. Schwarz RE, Smith DD. Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage. Ann Surg Oncol. 2007;14(2):317–328
  38. Schwarz RE, Smith DD. Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database. Ann Surg Oncol. 2006;13(9):1189–1200
  39. Ludwig MS, Goodman M, Miller DL, et al. Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer. Chest. 2005;128(3):1545–1550
  40. Koppie TM, Vickers AJ, Vora K, et al. Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed?. Cancer. 2006;107(10):2368–2374

PII: S1043-1489(08)00007-9

doi: 10.1053/j.scrs.2008.01.006

Seminars in Colon & Rectal Surgery
Volume 19, Issue 1 , Pages 26-29 , March 2008